Theoretical

Follow-Through in Synthetic Biology Research

I have just read a pair of papers, both of which outline theoretical methods of creating synchronised oscillation circuits in bacterial cells. Synchronising Genetic Relaxation Oscillators by Intercell Signalling Modelling a Synthetic Multicellular Clock: Repressilators Coupled by Quorum Sensing In essence, the idea is to make bacteria who “blink” as whole colonies, by creating and destroying a fluorescent protein in an on-off manner at the same time as a group. This has been done in single cells, but as you might imagine the pattern of on-off gets lost in the crowd of a whole colony of millions, so the effect isn’t clear to the naked eye.